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Effects of the intraperitoneal injection of HRW or VEH on the mechanical allodynia and thermal hyperalgesia induced by paw inflammation. Effects of the repetitive administration of HRW or VEH, injected at 1T and 2T per day, over the decreased von Frey filaments strength (g) ( A ) and the <t>withdrawal</t> <t>latency</t> (s) ( B ) generated by CFA in the ipsilateral <t>hind</t> paws. For each test, * indicates significant changes vs. their respective SS-injected mice (SS + VEH, SS + HRW 1T, or SS + HRW 2T), + represents significant differences vs. CFA + VEH injected mice, and # denotes significant differences vs. CFA + HRW 1T ( p < 0.05, on one-way ANOVA and Student–Newman–Keuls test). Data are presented as mean values ± SEM; n = 6 animals for group.
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Image Search Results


Effects of the intraperitoneal injection of HRW or VEH on the mechanical allodynia and thermal hyperalgesia induced by paw inflammation. Effects of the repetitive administration of HRW or VEH, injected at 1T and 2T per day, over the decreased von Frey filaments strength (g) ( A ) and the withdrawal latency (s) ( B ) generated by CFA in the ipsilateral hind paws. For each test, * indicates significant changes vs. their respective SS-injected mice (SS + VEH, SS + HRW 1T, or SS + HRW 2T), + represents significant differences vs. CFA + VEH injected mice, and # denotes significant differences vs. CFA + HRW 1T ( p < 0.05, on one-way ANOVA and Student–Newman–Keuls test). Data are presented as mean values ± SEM; n = 6 animals for group.

Journal: Antioxidants

Article Title: Treatment with Hydrogen-Rich Water Improves the Nociceptive and Anxio-Depressive-like Behaviors Associated with Chronic Inflammatory Pain in Mice

doi: 10.3390/antiox11112153

Figure Lengend Snippet: Effects of the intraperitoneal injection of HRW or VEH on the mechanical allodynia and thermal hyperalgesia induced by paw inflammation. Effects of the repetitive administration of HRW or VEH, injected at 1T and 2T per day, over the decreased von Frey filaments strength (g) ( A ) and the withdrawal latency (s) ( B ) generated by CFA in the ipsilateral hind paws. For each test, * indicates significant changes vs. their respective SS-injected mice (SS + VEH, SS + HRW 1T, or SS + HRW 2T), + represents significant differences vs. CFA + VEH injected mice, and # denotes significant differences vs. CFA + HRW 1T ( p < 0.05, on one-way ANOVA and Student–Newman–Keuls test). Data are presented as mean values ± SEM; n = 6 animals for group.

Article Snippet: Thermal hyperalgesia was assessed by measuring the hind limb withdrawal latency response in seconds when the animal was exposed to heat in the plantar test (Ugo Basile, Varese, Italy).

Techniques: Injection, Generated

Effects of the subplantar administration of HRW or VEH on the mechanical allodynia and thermal hyperalgesia generated by paw inflammation. Effects of the subplantar administration of HRW or VEH, injected at 2T per day, over the decreased von Frey filaments strength (g) ( A ) and withdrawal latency (s) ( B ) provoked by CFA in the ipsilateral hind paws. For each test, * indicates significant variations vs. SS-injected mice treated with VEH (SS + VEH), and + represents significant differences vs. CFA-injected mice treated with VEH (CFA + VEH) ( p < 0.05, one-way ANOVA and Student–Newman–Keuls test). Data are shown as mean values ± SEM; n = 6 animals for group.

Journal: Antioxidants

Article Title: Treatment with Hydrogen-Rich Water Improves the Nociceptive and Anxio-Depressive-like Behaviors Associated with Chronic Inflammatory Pain in Mice

doi: 10.3390/antiox11112153

Figure Lengend Snippet: Effects of the subplantar administration of HRW or VEH on the mechanical allodynia and thermal hyperalgesia generated by paw inflammation. Effects of the subplantar administration of HRW or VEH, injected at 2T per day, over the decreased von Frey filaments strength (g) ( A ) and withdrawal latency (s) ( B ) provoked by CFA in the ipsilateral hind paws. For each test, * indicates significant variations vs. SS-injected mice treated with VEH (SS + VEH), and + represents significant differences vs. CFA-injected mice treated with VEH (CFA + VEH) ( p < 0.05, one-way ANOVA and Student–Newman–Keuls test). Data are shown as mean values ± SEM; n = 6 animals for group.

Article Snippet: Thermal hyperalgesia was assessed by measuring the hind limb withdrawal latency response in seconds when the animal was exposed to heat in the plantar test (Ugo Basile, Varese, Italy).

Techniques: Generated, Injection